1st cardiovascular-kidney-metabolic syndrome guideline spotlights risk equations, GLP-1 therapies

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The American Heart Association and the American College of Cardiology have published the first clinical practice guideline on cardiovascular-kidney-metabolic syndrome.

The guideline, published June 9 in Circulation and JACC, establishes a four-stage classification system to assess how a patient’s heart, kidneys, and metabolism are functioning together. Nearly 90% of U.S. adults have at least one CKM risk factor, including excess weight, high blood pressure, abnormal lipids, elevated blood glucose or reduced kidney function, according to a June 9 AHA news release.

Key recommendations include using updated PREVENT equations to calculate 10- and 30-year cardiovascular risk, screening for social determinants of health such as food insecurity and housing instability, and coordinating interdisciplinary care across cardiology, nephrology and endocrinology. For the first time, the guideline formally recommends GLP-1-based therapies for select patients with obesity and/or Type 2 diabetes to reduce cardiac event risk. It also recognized metabolic and bariatric surgery as a treatment option.

The guideline was developed in collaboration with the American Diabetes Association, the Obesity Association and the American Society of Nephrology.

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